Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clustered DNA Damages Induced by X Rays in Human Cells

1 Jun 2002

Abstract excerpt

Although DNA DSBs are known to be important in producing the damaging effects of ionizing radiation in cells, bistranded clustered DNA damages-two or more oxidized bases, abasic sites or strand breaks on opposing DNA strands within a few helical turns-are postulated to be difficult to repair and thus to be critical radiation-induced lesions. Gamma rays can induce clustered damages in DNA in solution, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms
Share to Radiation Therapy and Dosimetry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12005538
DOI: 10.1667/0033-7587(2002)157[0611:cddibx]2.0.co;2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clustered DNA Damages Induced by X Rays in Human CellsPMID 12005538Read ↗

The Clustered DNA Lesions – Types, Pathways of Repair and Relevance to Human HealthSemantic proximity Read ↗

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?Semantic proximity Read ↗

Formation of Clustered DNA Damage after High-LET Irradiation: A ReviewSemantic proximity Read ↗

Clustered DNA damage induced by heavy ion particlesSemantic proximity Read ↗

Delayed repair of radiation induced clustered DNA damage: Friend or foe?Semantic proximity Read ↗

Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological SignificanceSemantic proximity Read ↗

Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions.Semantic proximity Read ↗

Processing of DNA damage clusters in human cells: current status of knowledgeSemantic proximity Read ↗

Biological consequences of formation and repair of complex DNA damage.Semantic proximity Read ↗

Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualizationSemantic proximity Read ↗

3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiationSemantic proximity Read ↗

Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.