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Article

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.

Nucleic acids research - 1 Mar 2010

Eccles Laura J, Lomax Martine E, O'Neill Peter

Abstract excerpt

Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell's repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleotides to give a variety of three-lesion clusters containing abasic sites and 8-oxo-7, 8-dihydroguanine to investigate if the hierarchy of lesion processing dictates...

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Identifiers

PMID: 19965771
DOI: 10.1093/nar/gkp1070
PMCID: PMC2831305

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Source receipt: pubmed, retrieved 7 Sept 2026.

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