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8-OxodGuo and Fapy•dG Mutagenicity in Escherichia coli Increases Significantly when They Are Part of a Tandem Lesion with 5-Formyl-2'-deoxyuridine.

Chemical research in toxicology - 19 Aug 2024

Dasgupta Srijana, Gao Shijun, Yang Haozhe, Greenberg Marc M, Basu Ashis K

Abstract excerpt

Tandem lesions, which are defined by two or more contiguously damaged nucleotides, are a hallmark of ionizing radiation. Recently, tandem lesions containing 5-formyl-2'-deoxyuridine (5-fdU) flanked by a 5'-8-OxodGuo or Fapy•dG were discovered, and they are more mutagenic in human cells than the isolated lesions. In the current study, we examined replication of these tandem lesions in Escherichia coli. Bypass...

Topics

Escherichia coli
8-Hydroxy-2'-Deoxyguanosine
Deoxyuridine
Mutagens
Deoxyguanosine
Mutation
Mutagenesis
DNA Damage

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39041427
DOI: 10.1021/acs.chemrestox.4c00231
PMCID: PMC11333159

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8-OxodGuo and Fapy•dG Mutagenicity in Escherichia coli Increases Significantly when They Are Part of a Tandem Lesion with 5-Formyl-2'-deoxyuridine.PMID 39041427Read ↗

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