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Dissecting Highly Mutagenic Processing of Complex Clustered DNA Damage in Yeast Saccharomyces cerevisiae.

Cells - 3 Sept 2021

Kozmin Stanislav G, Eot-Houllier Gregory, Reynaud-Angelin Anne, Gasparutto Didier, Sage Evelyne

Abstract excerpt

Clusters of DNA damage, also called multiply damaged sites (MDS), are a signature of ionizing radiation exposure. They are defined as two or more lesions within one or two helix turns, which are created by the passage of a single radiation track. It has been shown that the clustering of DNA damage compromises their repair. Unresolved repair may lead to the formation of double-strand breaks (DSB) or the induction...

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Identifiers

PMID: 34571958
DOI: 10.3390/cells10092309
PMCID: PMC8471780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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