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Article

Cooperation between p53 and p130(Rb2) in induction of cellular senescence.

Cell death and differentiation - 1 Feb 2006

Kapić A, Helmbold H, Reimer R, Klotzsche O, Deppert W, Bohn W

Abstract excerpt

To determine pathways cooperating with p53 in cellular senescence when the retinoblastoma protein (pRb)/p16INK4a pathway is defunct, we stably transfected the p16INK4a-negative C6 rat glioma cell line with a temperature-sensitive mutant p53. Activation of p53(Val-135) induces a switch in pocket protein expression from pRb and p107 to p130(Rb2) and stalls the cells in late G1, early S-phase at high levels of...

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PMID: 16123778
DOI: 10.1038/sj.cdd.4401756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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