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Article

A conformation hypothesis for the suppressor and promoter functions of p53 in cell growth control and in cancer.

Proceedings. Biological sciences - 22 Aug 1991

Milner J

Abstract excerpt

Cancer is a genetic disease caused by defective control of cell proliferation. As cancer cells divide, the genetic defect is inherited by each daughter cell, leading to tumour development with possible progression to malignancy. The identification of those genes linked with cancer is essential for our understanding of the regulation of cell proliferation and for the therapeutic management of cancer cell growth....

Topics

Cell Division
Genes, Tumor Suppressor
Genes, p53
Humans
Mutation
Neoplasms
Promoter Regions, Genetic
Protein Biosynthesis
Protein Conformation
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1682937
DOI: 10.1098/rspb.1991.0100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1682937-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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