IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population.

doi:10.1016/j.humimm.2009.06.013

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Article

IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population.

Human immunology - 1 Sept 2009

Aminkeng Folefac, Van Autreve Jan E, Weets Ilse, Quartier Erik, Van Schravendijk Chris, Gorus Frans K, Van der Auwera Bart J

Abstract excerpt

The evaluation of susceptibility loci in a registry-based setting could be an important addition to the current predictive and screening models in T1D. Therefore, the aim of this study was to evaluate the importance of one of these loci, IFIH1. T1D patients (n=1981), control subjects (n=2092) and 430 families were genotyped for HLA-DQ and IFIH1 nsSNP rs1990760 (Ala946Thr). In the association analysis, the allelic...

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PMID: 19539001
DOI: 10.1016/j.humimm.2009.06.013

Genes

IFIH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population.PMID 19539001Read ↗

IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population.Semantic proximity Read ↗

The association between the IFIH1 locus and type 1 diabetes.Semantic proximity Read ↗

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.Semantic proximity Read ↗

Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes.Semantic proximity Read ↗

Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III.Semantic proximity Read ↗

Hba1c levels are increased in patients with gestational diabetes carrying the T/T genotype of the rs1990760 polymorphism in the IFIH1 geneSemantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.Semantic proximity Read ↗

The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.Semantic proximity Read ↗

Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus.Semantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent mannerSemantic proximity Read ↗

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.Semantic proximity Read ↗

HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry.Semantic proximity Read ↗

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