Article
Claudin function in the thick ascending limb of Henle's loop.
Annals of the New York Academy of Sciences - 1 May 2009
Günzel Dorothee, Haisch Lea, Pfaffenbach Sandra, Krug Susanne M, Milatz Susanne, Amasheh Salah, Hunziker Walter, Müller Dominik
Abstract excerpt
During the past decade, claudins have been established as major determinants of paracellular permeablilty in epithelia. In the kidney, each nephron segment expresses a distinct pattern of claudins. Cells of the thick ascending limb of Henle's loop (TAL), which is characterized by high paracellular cation permeability, co-express an unusually large number of different claudins: claudin-10, -16, and -19 and,...
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