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Article

Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex.

The Journal of clinical investigation - 1 Feb 2008

Hou Jianghui, Renigunta Aparna, Konrad Martin, Gomes Antonio S, Schneeberger Eveline E, Paul David L, Waldegger Siegfried, Goodenough Daniel A

Abstract excerpt

Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an inherited disorder caused by mutations in the genes encoding the TJ proteins claudin-16 (CLDN16) and CLDN19; however, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18188451
DOI: 10.1172/JCI33970
PMCID: PMC2176193

Genes

CLDN19
CLDN16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18188451-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex.PMID 18188451Read ↗

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Claudin-16 affects transcellular Cl- secretion in MDCK cells.Semantic proximity Read ↗

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Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria.Semantic proximity Read ↗

Methods to analyze subcellular localization and intracellular trafficking of Claudin-16.Semantic proximity Read ↗

Identification of a Novel Homozygous Missense Mutation in the CLDN16 Gene to Decipher the Ambiguous Clinical Presentation Associated with Autosomal Dominant Hypocalcaemia and Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis in an Indian Family.Semantic proximity Read ↗

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