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Article

Claudin-16 affects transcellular Cl- secretion in MDCK cells.

The Journal of physiology - 1 Aug 2009

Günzel Dorothee, Amasheh Salah, Pfaffenbach Sandra, Richter Jan F, Kausalya P Jaya, Hunziker Walter, Fromm Michael

Abstract excerpt

Claudin-16 (paracellin-1) is a tight junction protein localized mainly in the thick ascending limb of Henle's loop and also in the distal nephron. Its defect causes familial hypomagnesaemia with hypercalciuria and nephrocalcinosis. This had been taken as an indication that claudin-16 conveys paracellular Mg(2+) and Ca(2+) transport; however, evidence is still conflicting. We studied paracellular ion...

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Source

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Identifiers

PMID: 19528248
DOI: 10.1113/jphysiol.2009.173401
PMCID: PMC2746610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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