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Article

Extracellular Mg(2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation.

Biochimica et biophysica acta - 1 Mar 2010

Ikari Akira, Kinjo Keishi, Atomi Kosuke, Sasaki Yohei, Yamazaki Yasuhiro, Sugatani Junko

Abstract excerpt

Claudin-16 is involved in the paracellular reabsorption of Mg(2+) in the thick ascending limb of Henle. Little is known about the mechanism regulating the tight junctional localization of claudin-16. Here, we examined the effect of Mg(2+) deprivation on the distribution and function of claudin-16 using Madin-Darby canine kidney (MDCK) cells expressing FLAG-tagged claudin-16. Mg(2+) deprivation inhibited the...

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Identifiers

PMID: 19914201
DOI: 10.1016/j.bbamem.2009.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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