Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerization

8 Oct 2015

Abstract excerpt

The molecular nature of tight junction architecture and permeability is a long-standing mystery. Here, by comprehensive biochemical, biophysical, genetic, and electron microscopic analyses of claudin-16 and -19 interactions--two claudins that play key polygenic roles in fatal human renal disease, FHHNC--we found that 1) claudin-16 and -19 form a stable dimer through cis association of transmembrane domains 3 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Neuroimaging Techniques and Applications
Share to Barrier Structure and Function Studies
Share to Neonatal and fetal brain pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26446843
DOI: 10.1091/mbc.e15-06-0422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerizationPMID 26446843Read ↗

Claudin function in the thick ascending limb of Henle's loop.Semantic proximity Read ↗

Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner.Semantic proximity Read ↗

Claudins in Renal Physiology and PathologySemantic proximity Read ↗

Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex.Semantic proximity Read ↗

Channel functions of claudins in the organization of biological systems.Semantic proximity Read ↗

Claudin-16 affects transcellular Cl- secretion in MDCK cells.Semantic proximity Read ↗

Methods to analyze subcellular localization and intracellular trafficking of Claudin-16.Semantic proximity Read ↗

Molecular basis of claudin-17 anion selectivity.Semantic proximity Read ↗

Physiology and function of the tight junction.Semantic proximity Read ↗

Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.Semantic proximity Read ↗

Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b.Semantic proximity Read ↗

Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.