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Article

Claudins and the kidney.

Journal of the American Society of Nephrology : JASN - 1 Jan 2015

Yu Alan S L

Abstract excerpt

Claudins are tight-junction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability and selectivity of different nephron segments along the renal tubule. In the proximal tubule, claudins have a role in the bulk reabsorption of salt and water. In the thick ascending limb, claudins are important for the...

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Identifiers

PMID: 24948743
DOI: 10.1681/ASN.2014030284
PMCID: PMC4279745

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