Article
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption.
Science (New York, N.Y.) - 2 Jul 1999
Simon D B, Lu Y, Choate K A, Velazquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S, Lifton R P
Abstract excerpt
Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance...
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