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Article

Causal Relationship Between Methotrexate and Chronic Obstructive Pulmonary Disease: A Study Based on Network Toxicology and Mendelian Randomization.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Xiang Ying-Xing, Zou Fang-Shu, Shi Mei-Feng, Xu Qiang

Abstract excerpt

Introduction: Previous studies have shown that methotrexate (MTX) may have potential effects on chronic obstructive pulmonary disease (COPD), but the specific causal relationship remains unclear. Objective: This research intends to investigate whether a potential causal association exists between MTX usage and the risk of developing COPD. Methods: To systematically explore the potential association between MTX...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42328420
DOI: 10.2147/COPD.S615799
PMCID: PMC13281881

Genes

ABL1
EP300
HDAC1
HIF1A
MAPK1
NFE2L2
NFKB1
PPARG
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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