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Article

Methylene tetrahydrofolate reductase gene polymorphisms and their association with methotrexate toxicity: a meta-analysis.

Pharmacogenetics and genomics - 1 Feb 2012

Spyridopoulou Kalliopi P, Dimou Niki L, Hamodrakas Stavros J, Bagos Pantelis G

Abstract excerpt

OBJECTIVE: A systematic review and a meta-analysis were conducted, to investigate the possible association of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms with adverse effects related to methotrexate (MTX). METHODS: A systematic literature search in PubMed retrieved a total of 44 studies (42 unique articles). Two polymorphisms were included in the meta-analysis: C677T and A1298C. Random effect...

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Source

Identifiers

PMID: 22143415
DOI: 10.1097/FPC.0b013e32834ded2a

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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