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Article

Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study.

Modern rheumatology - 1 Jul 2018

Hakamata Jun, Hashiguchi Masayuki, Kaneko Yuko, Yamaoka Kunihiro, Shimizu Mikiko, Maruyama Junya, Takeuchi Tsutomu, Mochizuki Mayumi

Abstract excerpt

OBJECTIVES: Methotrexate (MTX) is used as first-line treatment of rheumatoid arthritis (RA) worldwide. Large interindividual differences in MTX effectiveness and safety occur, and the most frequent adverse reaction is hepatotoxicity, although the main cause remains unknown. We investigated factors associated with MTX-induced hepatic enzyme elevation in a hospital-based cohort study. METHODS: Study participants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

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Source

Identifiers

PMID: 29252093
DOI: 10.1080/14397595.2017.1414765

Genes

ABCB1
ATIC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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