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Article

Genetic polymorphisms and clinical parameters associated with renal toxicity in Thai hematologic malignancy patients receiving high dose methotrexate.

Scientific reports - 27 Apr 2024

Pitakkitnukun Palada, Pongpitakmetha Thanakit, Suttichet Thitima Benjachat, Sukkummee Warumphon, Chariyavilaskul Pajaree, Polprasert Chantana

Abstract excerpt

High-dose methotrexate (HD-MTX) is a widely used chemotherapy regimen for hematologic malignancies such as lymphomas and acute lymphoblastic leukemia, but its use can lead to adverse effects, including acute kidney injury (AKI), impaired liver function, and mucositis, causing extended hospital stays and delayed subsequent chemotherapy. Our study aimed to investigate the predictive factors for renal toxicities...

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Identifiers

PMID: 38678107
DOI: 10.1038/s41598-024-60334-w
PMCID: PMC11055848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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