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Article

Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis.

Critical reviews in oncology/hematology - 1 May 2021

Maagdenberg Hedy, Oosterom Natanja, Zanen Jolanda, Gemmati Donato, Windsor Rachael E, Heil Sandra G, Esperón Patricia, Jabeen Shakila, Ruiz-Argüelles Guillermo J, Zolk Oliver, Hoerning Susanne, Sleurs Charlotte, Lopéz-Lopéz Elixabet, Moreno-Galván Mónica, van den Heuvel-Eibrink Marry M, Maitland-van der Zee Anke H, Carleton Bruce C

Abstract excerpt

Methotrexate (MTX), an important chemotherapeutic agent, is often accompanied with mucositis. The occurrence and severity are unpredictable and show large interindividual variability. In this study, we review and meta-analyze previously studied genetic variants in relation to MTX-induced mucositis. We conducted a systematic search in Medline and Embase. We included genetic association studies of MTX-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33794308
DOI: 10.1016/j.critrevonc.2021.103312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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