Article
Mechanisms in pulmonary toxicology.
Clinics in chest medicine - 1 Mar 2004
Delaunois Luc M
Abstract excerpt
Specific accumulation and biotransformation of drugs cause cell injury in the lung. Evoked mechanisms are oxidative injury, direct cytotoxic effects, intracellular deposition of phospholipids, and immune reaction. Individual susceptibility can be due to genetically determined metabolic idiosyncrasy or to immune-mediated hypersensitivity.
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