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Article

Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies.

Pharmacogenomics - 1 Aug 2014

Suthandiram Sujatha, Gan Gin-Gin, Zain Shamsul Mohd, Bee Ping-Chong, Lian Lay-Hoong, Chang Kian-Meng, Ong Tee-Chuan, Mohamed Zahurin

Abstract excerpt

AIM: Pharmacogenetics of methotrexate (MTX) contributes to interindividual differences in toxicity. We aimed to evaluate the impact of SNPs within the MTX pathway genes on MTX-induced toxicity and MTX plasma levels at 48 h following treatment in Asian adults with acute lymphoblastic leukemia or non-Hodgkin lymphoma. PATIENTS & METHODS: Patients (n = 71) were genotyped for MTHFR C677T, MTHFR A1298C, SLC19A1 G80A,...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25303299
DOI: 10.2217/pgs.14.97

Genes

MTHFR
ABCB1
ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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