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Rise of oligodendroglioma hypermutator phenotype from a subclone harboring TP53 mutation after TMZ treatment.

Brain tumor pathology - 1 Apr 2024

Higuchi Fumi, Uzuka Takeo, Matsuda Hadzki, Sumi Takuma, Iwata Kayoko, Namatame Takashi, Shin Masahiro, Akutsu Hiroyoshi, Ueki Keisuke

Abstract excerpt

Oligodendrogliomas characterized and defined by 1p/19q co-deletion are slowly growing tumors showing better prognosis than astrocytomas. TP53 mutation is rare in oligodendrogliomas while the vast majority of astrocytomas harbor the mutation, making TP53 mutation mutually exclusive with 1p/19q codeletion in lower grade gliomas virtually. We report a case of 51-year-old woman with a left fronto-temporal...

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PMID: 38294664
DOI: 10.1007/s10014-024-00477-w

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