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Article

Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure.

European biophysics journal : EBJ - 1 Jul 2009

Hübner B, Strickfaden H, Müller S, Cremer M, Cremer T

Abstract excerpt

Chromosome shattering has been described as a special form of mitotic catastrophe, which occurs in cells with unrepaired DNA damage. The shattered chromosome phenotype was detected after application of a methanol/acetic acid (MAA) fixation protocol routinely used for the preparation of metaphase spreads. The corresponding phenotype in the living cell and the mechanism leading to this mitotic catastrophe have...

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PMID: 19536536
DOI: 10.1007/s00249-009-0496-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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