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Article

Oxygen activation in neuronal NO synthase: resolving the consecutive mono-oxygenation steps.

The Biochemical journal - 15 Apr 2012

Papale Davide, Bruckmann Chiara, Gazur Ben, Miles Caroline S, Mowat Christopher G, Daff Simon

Abstract excerpt

The vital signalling molecule NO is produced by mammalian NOS (nitric oxide synthase) enzymes in two steps. L-arginine is converted into NOHA (Nω-hydroxy-L-arginine), which is converted into NO and citrulline. Both steps are thought to proceed via similar mechanisms in which the cofactor BH4 (tetrahydrobiopterin) activates dioxygen at the haem site by electron transfer. The subsequent events are poorly understood...

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Identifiers

PMID: 22300432
DOI: 10.1042/BJ20111644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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