Article
Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.
Acta crystallographica. Section D, Biological crystallography - 1 Jun 2014
Avella G, Ardiccioni C, Scaglione A, Moschetti T, Rondinelli C, Montemiglio L C, Savino C, Giuffrè A, Brunori M, Vallone B
Abstract excerpt
Neuroglobin is a member of the globin family involved in neuroprotection; it is primarily expressed in the brain and retina of vertebrates. Neuroglobin belongs to the heterogeneous group of hexacoordinate globins that have evolved in animals, plants and bacteria, endowed with the capability of reversible intramolecular coordination, allowing the binding of small gaseous ligands (O2, NO and CO). In a unique...
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