Article
Loss of caveolin-3 induced by the dystrophy-associated P104L mutation impairs L-type calcium channel function in mouse skeletal muscle cells.
The Journal of physiology - 1 May 2007
Couchoux Harold, Allard Bruno, Legrand Claude, Jacquemond Vincent, Berthier Christine
Abstract excerpt
Caveolins are membrane scaffolding proteins that associate with and regulate a variety of signalling proteins, including ion channels. A deficiency in caveolin-3 (Cav-3), the major striated muscle isoform, is responsible for skeletal muscle disorders, such as limb-girdle muscular dystrophy 1C (LGMD 1C). The molecular mechanisms leading to the muscle wasting that characterizes this pathology are poorly understood....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.