Article
Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2000
Galbiati F, Volonte D, Chu J B, Li M, Fine S W, Fu M, Bermudez J, Pedemonte M, Weidenheim K M, Pestell R G, Minetti C, Lisanti M P
Abstract excerpt
It recently was reported that Duchenne muscular dystrophy (DMD) patients and mdx mice have elevated levels of caveolin-3 expression in their skeletal muscle. However, it remains unknown whether increased caveolin-3 levels in DMD patients contribute to the pathogenesis of DMD. Here, using a genetic approach, we test this hypothesis directly by overexpressing wild-type caveolin-3 as a transgene in mice. Analysis of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.