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Article

Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development

24 Feb 2020

Abstract excerpt

ABSTRACT Myosin heavy chain-embryonic (MyHC-emb) is a skeletal muscle-specific contractile protein expressed during muscle development. Mutations in MYH3, the gene encoding MyHC-emb, lead to Freeman–Sheldon and Sheldon–Hall congenital contracture syndromes. Here, we characterize the role of MyHC-emb during mammalian development using targeted mouse alleles. Germline loss of MyHC-emb leads to neonatal and...

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PMID: 32094117
DOI: 10.1242/dev.184507

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