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Article

Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature.

American journal of physiology. Endocrinology and metabolism - 1 Sept 2009

Potenza Maria A, Gagliardi Sara, De Benedictis Leonarda, Zigrino Addolorata, Tiravanti Edy, Colantuono Giuseppe, Federici Antonio, Lorusso Loredana, Benagiano Vincenzo, Quon Michael J, Montagnani Monica

Abstract excerpt

Oxidative stress contributes to cardiovascular complications of diabetes, in part, by reducing the bioavailability of nitric oxide (NO). We investigated the mechanisms whereby the insulin sensitizer rosiglitazone may ameliorate oxidative stress in the vasculature of spontaneously hypertensive rats (SHR). Nine-week-old SHR were treated by gavage for 7 wk with rosiglitazone (5 mg x kg(-1) x day(-1)) or vehicle...

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Identifiers

PMID: 19531637
DOI: 10.1152/ajpendo.00291.2009
PMCID: PMC2739701

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PGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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