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Article

New mechanism of rosiglitazone to reduce neointimal hyperplasia: activation of glycogen synthase kinase-3beta followed by inhibition of MMP-9.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2009

Lee Choon-Soo, Kwon Yoo-Wook, Yang Han-Mo, Kim Sung-Hwan, Kim Tae-Youn, Hur Jin, Park Kyung-Woo, Cho Hyun-Jai, Kang Hyun-Jae, Park Young-Bae, Kim Hyo-Soo

Abstract excerpt

OBJECTIVE: Mechanism of neointimal hyperplasia after vascular injury includes activation of signaling pathways and matrix metalloproteinases (MMPs) that are involved in cell proliferation and migration. Rosiglitazone, a synthetic peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agoni...

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Source

Identifiers

PMID: 19201691
DOI: 10.1161/ATVBAHA.108.176230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19201691-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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