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Article

Sex-specific programming of hypertension in offspring of late-gestation diabetic rats.

Pediatric research - 1 Oct 2012

Katkhuda Ragheed, Peterson Emily S, Roghair Robert D, Norris Andrew W, Scholz Thomas D, Segar Jeffrey L

Abstract excerpt

BACKGROUND: The intrauterine environment strongly influences adult disease susceptibility. We used a rat model of third-trimester maternal diabetes to test the hypothesis that adult offspring exposed to hyperglycemia in utero display increased blood pressure and alterations in vascular responsiveness. METHODS: Diabetes was induced by streptozotocin injection to pregnant rats on gestation day 13 (term 21 d) and...

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Identifiers

PMID: 22805998
DOI: 10.1038/pr.2012.93
PMCID: PMC3607358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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