Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring.

PloS one - 1 Jan 2016

Xiao DaLiao, Wang Lei, Huang Xiaohui, Li Yong, Dasgupta Chiranjib, Zhang Lubo

Abstract excerpt

Fetal nicotine exposure increased risk of developing cardiovascular disease later in life. The present study tested the hypothesis that perinatal nicotine-induced programming of heart ischemia-sensitive phenotype is mediated by enhanced reactive oxygen species (ROS) in offspring. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps from day 4 of gestation to day 10 after birth, in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Coronary Circulation
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Reperfusion Injury

Share to Nicotine

Share to Protein Kinase C-epsilon

Share to Recovery of Function

Share to Ventricular Dysfunction, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 26918336
DOI: 10.1371/journal.pone.0150557
PMCID: PMC4769226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring.PMID 26918336Read ↗

Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspringSemantic proximity Read ↗

Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal lifeSemantic proximity Read ↗

Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal DiabetesSemantic proximity Read ↗

Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: role of protein kinase C epsilon.Semantic proximity Read ↗

Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life.Semantic proximity Read ↗

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late LifeSemantic proximity Read ↗

Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular diseaseSemantic proximity Read ↗

Sex-Specific Effects of Prenatal Hypoxia and a Placental Antioxidant Treatment on Cardiac Mitochondrial Function in the Young Adult OffspringSemantic proximity Read ↗

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury.Semantic proximity Read ↗

Mechanisms of immature myocardial tolerance to ischemia: phenotypic differences in antioxidants, stress proteins, and oxidases.Semantic proximity Read ↗

The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype.Semantic proximity Read ↗

Chronic Prenatal Hypoxia Induces Epigenetic Programming of PKCε Gene Repression in Rat HeartsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.