Article
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.
Circulation - 18 May 2004
Kishi Takuya, Hirooka Yoshitaka, Kimura Yoshikuni, Ito Koji, Shimokawa Hiroaki, Takeshita Akira
Abstract excerpt
BACKGROUND: Oxidative stress increases in hypertension. The aim of this study was to determine whether reactive oxygen species (ROS) are increased in the rostral ventrolateral medulla (RVLM) in the brainstem, where the vasomotor center is located, in stroke-prone spontaneously hypertensive rats (SHRSP), and, if so, to determine whether the increased ROS contribute to neural mechanisms of hypertension in SHRSP....
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