Article
Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress.
Hypertension (Dallas, Tex. : 1979) - 1 May 2003
Shimosawa Tatsuo, Ogihara Takehide, Matsui Hiromitsu, Asano Tomoichiro, Ando Katsuyuki, Fujita Toshiro
Abstract excerpt
Hypertension, insulin resistance, and obesity are common age-related metabolic disorders that are often associated with increased oxidative stress and the resultant vascular damage. Underlying mechanisms have been suggested, and age-related overproduction of oxidative stress is one possible candidate. Since we recently found a vasoactive peptide, adrenomedullin, to be an endogenous antioxidant that potently...
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