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Article

Crumbs is required to achieve proper organ size control during Drosophila head development.

Development (Cambridge, England) - 1 Feb 2010

Richardson Emily C N, Pichaud Franck

Abstract excerpt

Crumbs (Crb) is a conserved apical polarity determinant required for zonula adherens specification and remodelling during Drosophila development. Interestingly, crb function in maintaining apicobasal polarity appears largely dispensable in primary epithelia such as the imaginal discs. Here, we sh...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20110329
DOI: 10.1242/dev.041913
PMCID: PMC2827617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20110329-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Crumbs is required to achieve proper organ size control during Drosophila head development.PMID 20110329Read ↗

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CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.Semantic proximity Read ↗

Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster.Semantic proximity Read ↗

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

The Hippo pathway regulates apical-domain size independently of its growth-control function.Semantic proximity Read ↗

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.Semantic proximity Read ↗

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.Semantic proximity Read ↗

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