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Article

The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs.

The Journal of cell biology - 5 Mar 2018

Forest Elodie, Logeay Rémi, Géminard Charles, Kantar Diala, Frayssinoux Florence, Heron-Milhavet Lisa, Djiane Alexandre

Abstract excerpt

During development, cell numbers are tightly regulated, ensuring that tissues and organs reach their correct size and shape. Recent evidence has highlighted the intricate connections between the cytoskeleton and the regulation of the key growth control Hippo pathway. Looking for apical scaffolds regulating tissue growth, we describe that Drosophila melanogaster big bang (Bbg), a poorly characterized multi-PDZ...

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Identifiers

PMID: 29326287
DOI: 10.1083/jcb.201705107
PMCID: PMC5839784

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