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Article

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling.

Current biology : CB - 4 Apr 2006

Maitra Sushmita, Kulikauskas Rima M, Gavilan Heather, Fehon Richard G

Abstract excerpt

The precise coordination of signals that control proliferation is a key feature of growth regulation in developing tissues . While much has been learned about the basic components of signal transduction pathways, less is known about how receptor localization, compartmentalization, and trafficking affect signaling in developing tissues. Here we examine the mechanism by which the Drosophila Neurofibromatosis 2...

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Source

Identifiers

PMID: 16581517
DOI: 10.1016/j.cub.2006.02.063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling.PMID 16581517Read ↗

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.Semantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin.Semantic proximity Read ↗

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.Semantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.Semantic proximity Read ↗

ERM proteins regulate growth cone responses to Sema3A.Semantic proximity Read ↗

Merlin regulates signaling events at the nexus of development and cancerSemantic proximity Read ↗

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.Semantic proximity Read ↗

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