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Article

Dysfunction of phospholipase Cγ in immune disorders and cancer.

Trends in biochemical sciences - 1 Dec 2014

Koss Hans, Bunney Tom D, Behjati Sam, Katan Matilda

Abstract excerpt

The surge in genetic and genomic investigations over the past 5 years has resulted in many discoveries of causative variants relevant to disease pathophysiology. Although phospholipase C (PLC) enzymes have long been recognized as important components in intracellular signal transmission, it is only recently that this approach highlighted their role in disease development through gain-of-function mutations. In...

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PMID: 25456276
DOI: 10.1016/j.tibs.2014.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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