Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance.

EMBO reports - 1 Sept 2025

Zeng Longhui, Zhang Xinyan, Xiong Yiwei, Sato Kazuki, Hajicek Nicole, Kogure Yasunori, Kataoka Keisuke, Ogawa Seishi, Sondek John, Su Xiaolei

Abstract excerpt

Phospholipase C gamma 1 (PLCG1) has been identified as the most frequently mutated gene in adult T-cell leukemia/lymphoma, suggesting a critical function of PLCG1 in driving T cell activation. However, it remains unclear how these mutations regulate T cell physiology and pathology. Here, we investigate three common leukemia/lymphoma-associated mutations (R48W, S345F, and D1165H). We discover that these mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Jurkat Cells

Share to Lymphocyte Activation

Share to Phospholipase C gamma

Share to T-Lymphocytes

Share to Vorinostat

Source

Open in PubMed Open full text

Identifiers

PMID: 40796680
DOI: 10.1038/s44319-025-00546-x
PMCID: PMC12457681

Genes

PLCG1
LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance.PMID 40796680Read ↗

A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.Semantic proximity Read ↗

PLCG1 mutations in cutaneous T-cell lymphomas.Semantic proximity Read ↗

TCR Pathway Mutations in Mature T Cell Lymphomas.Semantic proximity Read ↗

Characterization of phospholipase C gamma enzymes with gain-of-function mutations.Semantic proximity Read ↗

Variegated RHOA mutations in adult T-cell leukemia/lymphoma.Semantic proximity Read ↗

A critical role for PLCG1 in RAS activation by BCR-ABL1 and FLT3-ITDSemantic proximity Read ↗

PLCG1 Gene Mutations in Cutaneous T-Cell Lymphomas Revisited.Semantic proximity Read ↗

RAC1 signaling in polyploid giant cancer cells: Implications for tumorigenesis and therapy resistance.Semantic proximity Read ↗

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.Semantic proximity Read ↗

Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure.Semantic proximity Read ↗

Aberrant phospholipase C gamma 1 activity promotes CTCL growth.Semantic proximity Read ↗

Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.