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Article

Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C.

The EMBO journal - 15 Nov 1999

Zhang Y, Altshuller Y M, Hammond S M, Hayes F, Morris A J, Frohman M A

Abstract excerpt

Activation of phosphatidylcholine-specific phospholipase D (PLD) constitutes an important part of the cellular response to agonist signaling. PLD1 is stimulated in vitro in a direct and synergistic manner by protein kinase C (PKC), ADP-ribosylation factor (ARF) and Rho family members. However, the direct and specific role of each of these effectors in agonist-stimulated PLD activation is poorly understood. We...

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Source

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Identifiers

PMID: 10562546
DOI: 10.1093/emboj/18.22.6339
PMCID: PMC1171697

Genes

PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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