Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2009

Mohamedali Azim M, Smith Alexander E, Gaken Joop, Lea Nicholas C, Mian Syed A, Westwood Nigel B, Strupp Corinna, Gattermann Norbert, Germing Ulrich, Mufti Ghulam J

Abstract excerpt

PURPOSE: Cryptic chromosomal aberrations, such as regions of uniparental disomy (UPD), have been shown to harbor homozygous mutations and are a common feature in myelodysplastic syndrome (MDS). We investigated the sequence integrity of 4q24 candidate tumor suppressor gene TET2 in MDS patients with UPD on chromosome 4. PATIENTS AND METHODS: The coding exons of TET2 were analyzed by 454 deep sequencing and Sanger...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 4

Share to Dioxygenases

Share to DNA-Binding Proteins

Share to Myelodysplastic Syndromes

Share to Proto-Oncogene Proteins

Share to Uniparental Disomy

Source

Identifiers

PMID: 19528370
DOI: 10.1200/JCO.2009.22.6985

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome.PMID 19528370Read ↗

Acquired mutations in TET2 are common in myelodysplastic syndromes.Semantic proximity Read ↗

Mutation in TET2 in myeloid cancers.Semantic proximity Read ↗

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms.Semantic proximity Read ↗

TET2 mutations in myelodysplasia and myeloid malignancies.Semantic proximity Read ↗

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value.Semantic proximity Read ↗

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.Semantic proximity Read ↗

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).Semantic proximity Read ↗

Mutational Profile Enables the Identification of a High Risk Subgroup in Myelodysplastic Syndromes With Isolated Trisomy 8Semantic proximity Read ↗

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.Semantic proximity Read ↗

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.Semantic proximity Read ↗

TET2 deletions are a recurrent but rare phenomenon in myeloid malignancies and are frequently accompanied by TET2 mutations on the remaining allele.Semantic proximity Read ↗

TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.