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Article

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

Blood - 8 Oct 2009

Kosmider Olivier, Gelsi-Boyer Véronique, Cheok Meyling, Grabar Sophie, Della-Valle Véronique, Picard Françoise, Viguié Franck, Quesnel Bruno, Beyne-Rauzy Odile, Solary Eric, Vey Norbert, Hunault-Berger Mathilde, Fenaux Pierre, Mansat-De Mas Véronique, Delabesse Eric, Guardiola Philippe, Lacombe Catherine, Vainchenker William, Preudhomme Claude, Dreyfus François, Bernard Olivier A, Birnbaum Daniel, Fontenay Michaëla

Abstract excerpt

Oncogenic pathways underlying in the development of myelodysplastic syndromes (MDS) remain poorly characterized, but mutations of the ten-eleven translocation 2 (TET2) gene are frequently observed. In the present work, we evaluated the prognostic impact of TET2 mutations in MDS. Frameshift, nonse...

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Identifiers

PMID: 19666869
DOI: 10.1182/blood-2009-04-215814

Genes

TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19666869-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).PMID 19666869Read ↗

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.Semantic proximity Read ↗

Acquired mutations in TET2 are common in myelodysplastic syndromes.Semantic proximity Read ↗

Prognostic significance of TET2 mutations in myelodysplastic syndromes: A meta-analysis.Semantic proximity Read ↗

TET2 mutations in myelodysplasia and myeloid malignancies.Semantic proximity Read ↗

Clinical characteristics and prognostic analysis of gene mutations in Myelodysplastic SyndromeSemantic proximity Read ↗

[Molecular and clinical characteristics and prognosis of myelodysplastic neoplasms with biallelic TET2 inactivation].Semantic proximity Read ↗

Mutation status and burden can improve prognostic prediction of patients with lower-risk myelodysplastic syndromes.Semantic proximity Read ↗

TET2 mutations in secondary acute myeloid leukemias: a French retrospective study.Semantic proximity Read ↗

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value.Semantic proximity Read ↗

Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms.Semantic proximity Read ↗

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.Semantic proximity Read ↗

Analysis of the Ten-Eleven Translocation 2 (TET2) gene mutation in myeloproliferative neoplasms.Semantic proximity Read ↗

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