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Article

ADH1A variation predisposes to personality traits and substance dependence.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2010

Zuo Lingjun, Gelernter Joel, Kranzler Henry R, Stein Murray B, Zhang Huiping, Wei Feng, Sen Srijan, Poling James, Luo Xingguang

Abstract excerpt

Human personality traits are strong predictors or characteristics of many psychiatric disorders including substance dependence (SD). Recently, significant associations between alcohol dehydrogenase type 1A gene (ADH1A) and SD have been reported, which led us to investigate the impact of ADH1A variation on personality traits and risk of SD. Five hundred fifty-eight subjects with SD [398 European-Americans (EAs)...

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Identifiers

PMID: 19526455
DOI: 10.1002/ajmg.b.30990
PMCID: PMC2861415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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