A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.

doi:10.1371/journal.pone.0049368

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Article

A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.

PloS one - 1 Jan 2013

Zayats Tetyana, Yang Bao-Zhu, Xie Pingxing, Poling James, Farrer Lindsay A, Gelernter Joel

Abstract excerpt

BACKGROUND: Personality correlates highly with both cocaine and nicotine dependencies (CD, ND), and their co-morbid psychopathologies. However, little is known about the nature of these relationships. This study examined if environment (marriage) or genetics (a single SNP, CHRNA5*rs16969968) would moderate the correlation of personality with CD, ND and cocaine-induced paranoia (CIP) in African and European...

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Identifiers

PMID: 23308091
DOI: 10.1371/journal.pone.0049368
PMCID: PMC3538653

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CHRNA5

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Source receipt: pubmed, retrieved 7 Sept 2026.

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