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Article

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

Nature neuroscience - 1 Jul 2009

Morfini Gerardo A, You Yi-Mei, Pollema Sarah L, Kaminska Agnieszka, Liu Katherine, Yoshioka Katsuji, Björkblom Benny, Coffey Eleanor T, Bagnato Carolina, Han David, Huang Chun-Fang, Banker Gary, Pigino Gustavo, Brady Scott T

Abstract excerpt

Selected vulnerability of neurons in Huntington's disease suggests that alterations occur in a cellular process that is particularly critical for neuronal function. Supporting this idea, pathogenic Htt (polyQ-Htt) inhibits fast axonal transport (FAT) in various cellular and animal models of Huntington's disease (mouse and squid), but the molecular basis of this effect remains unknown. We found that polyQ-Htt...

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Identifiers

PMID: 19525941
DOI: 10.1038/nn.2346
PMCID: PMC2739046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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