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Article

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.

Nature medicine - 1 Mar 2011

Song Wenjun, Chen Jin, Petrilli Alejandra, Liot Geraldine, Klinglmayr Eva, Zhou Yue, Poquiz Patrick, Tjong Jonathan, Pouladi Mahmoud A, Hayden Michael R, Masliah Eliezer, Ellisman Mark, Rouiller Isabelle, Schwarzenbacher Robert, Bossy Blaise, Perkins Guy, Bossy-Wetzel Ella

Abstract excerpt

Huntington's disease is an inherited and incurable neurodegenerative disorder caused by an abnormal polyglutamine (polyQ) expansion in huntingtin (encoded by HTT). PolyQ length determines disease onset and severity, with a longer expansion causing earlier onset. The mechanisms of mutant huntingtin-mediated neurotoxicity remain unclear; however, mitochondrial dysfunction is a key event in Huntington's disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21336284
DOI: 10.1038/nm.2313
PMCID: PMC3051025

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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