Article
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.
Neuron - 25 Sept 2003
Gunawardena Shermali, Her Lu-Shiun, Brusch Richard G, Laymon Robert A, Niesman Ingrid R, Gordesky-Gold Beth, Sintasath Louis, Bonini Nancy M, Goldstein Lawrence S B
Abstract excerpt
We tested whether proteins implicated in Huntington's and other polyglutamine (polyQ) expansion diseases can cause axonal transport defects. Reduction of Drosophila huntingtin and expression of proteins containing pathogenic polyQ repeats disrupt axonal transport. Pathogenic polyQ proteins accumulate in axonal and nuclear inclusions, titrate soluble motor proteins, and cause neuronal apoptosis and organismal...
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