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Article

A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project.

American journal of human genetics - 1 Jun 2005

Souto Juan Carlos, Blanco-Vaca Francisco, Soria José Manuel, Buil Alfonso, Almasy Laura, Ordoñez-Llanos Jordi, Martín-Campos Jesús Ma, Lathrop Mark, Stone William, Blangero John, Fontcuberta Jordi

Abstract excerpt

Homocysteine (Hcy) plasma level is an independent risk marker for venous thrombosis, myocardial infarction, stroke, congestive heart failure, osteoporotic fractures, and Alzheimer disease. Hcy levels are determined by the interaction of genetic and environmental factors. The genetic basis is still poorly understood, since only the MTHFR 677 C-->T polymorphism has been consistently associated with plasma Hcy...

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Share to Chromosomes, Human, Pair 11
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15849667
DOI: 10.1086/430409
PMCID: PMC1196452

Genes

NNMT
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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