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Article

HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.

Molecular cell - 12 Jun 2009

Rattner Barbara P, Yusufzai Timur, Kadonaga James T

Abstract excerpt

The high-mobility group N (HMGN) proteins are abundant nonhistone chromosomal proteins that bind specifically to nucleosomes at two high-affinity sites. Here we report that purified recombinant human HMGN1 (HMG14) and HMGN2 (HMG17) potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins. In contrast, mutant HMGN proteins with double Ser-to-Glu mutations in their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19524541
DOI: 10.1016/j.molcel.2009.04.014
PMCID: PMC2709789

Genes

HMGN2
HMGN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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