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Article

Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter.

Molecular cell - 12 Jun 2009

Palmer Adam C, Ahlgren-Berg Alexandra, Egan J Barry, Dodd Ian B, Shearwin Keith E

Abstract excerpt

Elongating RNA polymerases (RNAPs) can interfere with transcription from downstream promoters by inhibiting DNA binding by RNAP and activators. However, combining quantitative measurement with mathematical modeling, we show that simple RNAP elongation cannot produce the strong asymmetric interference observed between a natural face-to-face promoter pair in bacteriophage lambda. Pausing of elongating polymerases...

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Share to Bacteriophage lambda
Share to Binding Sites
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 19524535
DOI: 10.1016/j.molcel.2009.04.018
PMCID: PMC2697128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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